We develop application-oriented solutions for synthetic biofilms for you – precise, sprayable and ready for use in research and industry.

Fundamentals

Bacteria exist in two fundamental organizational forms: freely dissolved in liquid or as a structured compound in so-called biofilms. Under natural conditions, biofilms dominate – for example as slimy layers on stones in bodies of water or as deposits in pipe systems.

In technical applications, biofilms have long been more than just a biological phenomenon. They take on central functions in wastewater treatment, in microbial energy production or in fermentative processes. However, natural biofilm formation is difficult to control in many cases: formation takes time, colonization is not uniform and productivity remains limited.

This is where we come in: With synthetic, sprayable biofilms, we are developing a platform technology that can be used in a targeted and reproducible manner – regardless of the randomness of natural colonization processes. The aim is to shape biofilms in a controlled manner and make them technically usable.

Synthetic biofilms

Spraymatiq’s key innovation is the development of synthetic biofilms based on hydrogels. This artificial matrix enables the targeted immobilization of microorganisms and at the same time offers control over key parameters such as cell density, biofilm volume or conductivity.

Compared to natural biofilms, the synthetic approach allows significantly improved process control. In bioelectrochemical systems, for example, increased productivity has been demonstrated – published and secured by a patent (Knoll et al., 2022).

In addition, synthetic biofilms are highly resilient to external disruptive factors such as radiation or chemical contaminants. The symbiotic growth of different microorganisms creates synergistic effects in the metabolic pathways, making it possible to realize complex reactions in the smallest of spaces. In this way, toxic intermediate products can be avoided and additional energy input can be reduced – thus significantly lowering both process and investment costs.

Another key to technical implementation is our form of application: the biofilms are applied using a specially developed spray system. This allows them to be applied to technical surfaces quickly, reproducibly and over a large area – a clear advantage for integration into existing processes. Different morphologies or co-substrates can also be applied in a targeted manner.

Even though many microorganisms are fundamentally capable of forming biofilms, the knowledge required to specifically promote these processes is often lacking. With sprayable biofilms, robust, functional biofilm systems can be created in a fraction of the usual time – and on almost any scale.

Research opportunities

We are working on scalable solutions for biotechnological processes in which biological stability, productivity and technical connectivity are crucial. This enables us to develop, apply and integrate synthetic biofilms in a targeted manner.

Our focus areas:

  • Development and productivity analysis with industry-related microorganisms
    Investigation of synthetic biofilms for specifically selected organisms from industrial processes. The aim is effective cell immobilization and higher productivity through locally increased cell densities – significantly improved compared to natural biofilms.
  • Technological implementation as a sprayable biofilm
    Analysis and further development of synthetic biofilms for use as sprayable biofilms with a focus on simple, uniform application in the existing system environment.
  • Transferability and simplification of application
    Systematic adaptation of the developed solutions for on-site application. The transfer from the laboratory to real processes is carried out with the aim of significantly simplifying practical application.
  • Expert advice on biofilms and biomaterials
    Support in the development of biofilm-supported applications as well as general questions on biofilm behavior, material selection or system integration.


Contact us, we will support you in the development and application of synthetic biofilms.

Our team

Prof. Dr. Johannes Gescher

Principal Investigator

Dr. Laura Philipp

Chief engineer

Dr. Jonas Lapp

Bioinformatician

How to reach us.

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    Contact

    micromatiq

    Technische Universität Hamburg
    Institut für Technische Mikrobiologie V-7
    Kasernenstraße 12 (F)
    21073 Hamburg

    Copyright 2025